Vor 50 Jahren: Erste erfolgreiche Behandlung einer akuten Herztransplantat-Abstoßungskrise

Abstract

The first clinical use of the “Munich antilymphocyte globulin” (ALG) at the occasion of the first successful human heart transplantation is briefly described. The cardiac transplantation was carried out by Christiaan Barnard and his team in Cape Town, South Africa, in 1968. The patient developed an acute allograft rejection which could be successfully reversed within three weeks using the intravenous administration of ALG. This event can be regarded as the beginning of a success story of ALG in its use as a powerful immunosuppressive agent in all categories of clinical organ transplantation.

Herztransplantationen werden in der modernen Medizin als Routinebehandlungen gewertet und haben sich zur Standardtherapie bei terminalem Herzversagen entwickelt. Derzeit wird die Anzahl der weltweiten Herztransplantationen auf ca. 5500 Eingriffe jährlich geschätzt [1]. Die Anfänge dieser chirurgischen Behandlungsmethode wurden einst als spektakuläre, medienwirksame Ereignisse gefeiert.

Schlüsselwörter

Münchener Antilymphozytenglobulin - erste erfolgreiche Herztransplantation

Key words

Munich antilymphocyte globulin - first successful heart transplantation

• Literatur

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