Synlett 2007(18): 2785-2791  
DOI: 10.1055/s-2007-990840
ACCOUNT
© Georg Thieme Verlag Stuttgart · New York

Progress in Coenzyme NADH Model Compounds and Asymmetric Reduction of Benzoylformate

Nai-Xing Wang*, Jia Zhao
Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100080, P. R. of China
Fax: +86(10)62554670; e-Mail: nxwang@mail.ipc.ac.cn;
Further Information

Publication History

Received 18 April 2007
Publication Date:
12 October 2007 (online)

Abstract

Nicotinamide adenine dinucleotide hydrogen (NADH) could play an important role in living systems and this has stimulated a great deal of interest in the fields of bioorganic and organic chemistry. A large number of NADH model compounds have been developed for studying stereoselective reduction. Herein, the factors involved in stereoselective reduction using NADH model compounds are discussed and the progress of research on coenzyme NADH model compounds is summarized.

1 Introduction

2 Factors of Stereoselective Reduction Using NADH Models

2.1 Effect of a Remote Sterically Demanding Side Chain

2.2 Effect of a Substituent at C-4 of the Dihydropyridine Ring

2.3 Effect of a Special Conformation

3 Conclusion