Organocatalytic Biomimetic Reduction of Conjugated Nitroalkenes

Zhiguo Zhang; Peter R. Schreiner

doi:10.1055/s-2007-983805

SPECIALTOPIC

Organocatalytic Biomimetic Reduction of Conjugated Nitroalkenes

Zhiguo Zhang, Peter R. Schreiner*
Institut für Organische Chemie, Justus-Liebig-Universität Gießen, Heinrich-Buff-Ring 58, 35392 Gießen, Germany
Fax: +49(641)9934309; e-Mail: prs@org.chemie.uni-giessen.de;

Abstract

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Abstract

A thiourea-catalyzed biomimetic reduction of conjugated nitroalkenes has been developed. Various aromatic and aliphatic conjugated nitroalkenes can be reduced to give the respective nitroalkanes with good yields under mild conditions. This protocol is not only practical, but may also provide insight into the mechanisms of redox transformations in biological systems.

Key words

biomimetic reduction - Hantzsch ester - hydrogen bonding - nitroalkenes - thiourea

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References

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