Synthesis and Resolution of the Benzomorphan-Based Kappa Opioid Agonist Bremazocine

Abstract

An efficient synthesis of racemic bremazocine hydrochloride salt was developed. The racemic material was resolved using (+)- and (-)-3-bromocamphorsulfonic acid ammonium salt to give optically pure samples of (-)- and (+)-bremazocine.

Key words

bremazocine - kappa opioid agonist - synthesis - medicinal chemistry - receptors

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