Acylbenzotriazoles as Advantageous N-, C-, S-, and O-Acylating Agents

Abstract

N-Acylbenzotriazoles are useful acylating agents, especially where the corresponding acid chlorides are unstable, difficult to prepare, or unknown. Reactions with N-acylbenzotriazoles offer efficient transformations under mild conditions, and provide an alternative convenient procedure for N-, C-, S-, and O-acylation. In this account, our work mainly carried out from 2000 to early 2005 is discussed.

1 Introduction

2 N-Acylation

3 S-Acylation

4 C-Acylation of Heterocycles

5 C-Acylation of Ketones, Cyanides and Sulfones

6 Preparation of β-Ketoesters and β-Diketones by Acylative Deacetylation

7 Conclusion

Key words

Benzotriazole methodology - N-acylbenzotriazoles - acylating agent - N-acylation - C-acylation - S-acylation - O-acylation

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7

Katritzky, A. R.; Angrish, P.; Suzuki, K. in preparation.