Abstract
The incorporation of metal binding sites into peptides is an
elegant method for the stabilization of peptide microstructures. In
order to do this, first amino acid derivatives have to be synthesized
which bear metal ligand moieties like bipyridines, phosphanes, or
catechols. By standard peptide coupling reactions those building
blocks can be incorporated into peptide strands. Examples from the
literature show that, depending on the system, different peptide
structures are stabilized by addition of metal ions to appropriate
artificial peptides. Thus, conformationally fixed α-helix-, β-sheet-
or various turn/loop-motifs can be obtained.
1 Introduction
2 Peptide/Metal-Ligand Hybrids
2.1 Pyridine-Based (and Related) Ligands
2.1.1 Preparation of Bipyridine Amino Acids
2.1.2 Preparation of Peptide Derivatives and their Metal Complexes
2.2 Phosphane-Based Ligands
2.3 Catechol-Based Ligands
2.3.1 Amino Acid-Bridged Dicatechol Ligands
2.3.2 Peptide-Bridged Dicatechol Ligands
3 Miscellaneous
4 Conclusion
Key words
bioorganic chemistry - peptides - ligands - coupling - complexes
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