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Synthesis 2003(6): 0899-0905
DOI: 10.1055/s-2003-38681
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of New 1,2,4- and 1,3,4-Oxadiazole Derivatives

Emerson Meyer, Antonio C. Joussef, Hugo Gallardo*
Departamento de Química, Universidade Federal de Santa Catarina, Florianópolis, SC - 88040-900, Brazil
Fax: +55(48)3319711; e-Mail: hugo@qmc.ufsc.br ;
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Publikationsverlauf

Received 9 December 2002
Publikationsdatum:
16. April 2003 (online)

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Abstract

A novel series of compounds structurally related to nonpeptide angiotensin II (AII) receptor antagonists has been prepared. In these compounds, the ‘spacer’ phenyl ring commonly found in almost all AII receptor antagonists was replaced by 1,2,4- and 1,3,4-oxadiazole rings.

Key words

hypertension - heterocycles - drugs - quinolines - antagonists - oxadiazoles

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