Synthesis of New 1,2,4- and 1,3,4-Oxadiazole Derivatives

Abstract

A novel series of compounds structurally related to nonpeptide angiotensin II (AII) receptor antagonists has been prepared. In these compounds, the ‘spacer’ phenyl ring commonly found in almost all AII receptor antagonists was replaced by 1,2,4- and 1,3,4-oxadiazole rings.

hypertension - heterocycles - drugs - quinolines - antagonists - oxadiazoles

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