Solution- and Solid-Phase Approaches in Asymmetric Phase-Transfer Catalysis by Cinchona Alkaloid Derivatives

Abstract

The catalytic asymmetric alkylation under phase-transfer conditions of various substrates (enones, α-fluoro ketones, glycine-imines) promoted by chiral quaternary ammonium salts derived from cinchona alkaloids is described. A solvent-free phase-transfer catalysis is presented as well as a new type of polymer-supported phase-transfer catalyst derived from cinchona alkaloids.

Key words

phase-transfer catalysis - polymers - Michael addition - fluorine - asymmetric catalysis

References

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