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Activation of C-H Bonds α to Nitriles for Combinatorial Chemistry: Ruthenium-Catalyzed Aldol and Michael Reactions of Polymer-Supported Nitriles
31 December 2001 (online)
Catalytic activation of C-H bonds adjacent to nitriles supported by Wang resin can be performed with ruthenium dihydride complex RuH2(PPh3)4 (1). Aldol and Michael reactions of the solid-supported cyanoacetates proceed to give the corresponding adducts in good yields under mild and neutral conditions. Four-component reactions that include sequential aldol-Michael-Michael reaction by C-H activation take place diastereoselectively.
ruthenium - C-H activations - solid-phase synthesis - nitriles - aldol reactions - Michael additions