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Synlett 2001; 2001(5): 0582-0589
DOI: 10.1055/s-2001-13350
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Specifying Non-Covalent Interactions: Sequence-Specific Assembly of Hydrogen-Bonded Molecular Duplexes

Bing Gong*
  • *Department of Chemistry, Natural Sciences Complex, State University of New York, Buffalo, NY 14260, USA; Fax + 1(716)645 6963; E-mail: bgong@acsu.buffalo.edu
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Publication Date:
31 December 2001 (online)

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The recombination of amide O and H atoms, the simplest hydrogen bond donors and acceptors, has lead to the sequence-specific formation of molecular duplexes from single molecular strands of complementary H-binding sequences. The sequences are programmable. The stability of the duplexes is adjustable by changing the number of H-bonding sites. Synthesis of these molecular strands involves standard amide/peptide chemistry. These molecular strands represent unnatural information-storing molecules that are being used as basic recognition units in designing a variety of supramolecular structures.

amides - DNA - molecular recognition - peptides - supramolecular chemistry