Synthesis 2000; 2000(14): 1979-2000
DOI: 10.1055/s-2000-8715
review
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Chiral Ketone-Catalyzed Asymmetric Epoxidation of Olefins

Michael Frohn* , Yian Shi
  • *Department of Chemistry, Colorado State University, Fort Collins, CO 80523, USA; Fax +1(970)4 91 18 01; E-mail: [email protected]
Further Information

Publication History

Publication Date:
31 December 2000 (online)

Dioxiranes are remarkably versatile oxidizing agents that show encouraging potential for asymmetric synthesis, particularly asymmetric epoxidation of unfunctionalized olefins. This review outlines the recent development in this area. Discussions are focused on the structural requirements of the chiral ketone catalysts, how structural changes effect the reactivity and selectivity of the catalyst, reaction conditions, and transition states.