Nucleophilic Additions to Chiral Nitrones: New Approaches to Nitrogenated Compounds
31 December 2000 (online)
The reaction of optically active α-alkoxy and α-amino nitrones with a variety of nucleophiles serves as a useful process for the stereocontrolled synthesis of enantiomerically pure hydroxylamines having additional functionalities. These hydroxylamines can be used as key intermediates in the synthesis of a wide range of nitrogenated compounds including amino acids, carbohydrates, nucleoside analogs and pyrrolidines.
nitrones - hydroxylamines - carbohydrates - nucleosides - amino acids