Synthesis 2000; 2000(1): 1-64
DOI: 10.1055/s-2000-6217
review
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Sulfoximines: Structures, Properties and Synthetic Applications

Michael Reggelin* , Cornelia Zur
  • *Fachbereich Chemie und Pharmazie der Johannes Gutenberg-Universität Mainz, Duesbergweg 10-14, 55099 Mainz, Germany; Fax +49 (61 31) 39 47 78; E-mail: [email protected]; Homepage: http://cortex.chemie.uni-mainz.de
Further Information

Publication History

Publication Date:
31 December 2000 (online)

This review presents a comprehensive treatment of sulfoximine chemistry particularly emphasising synthetic developments and structural work after 1985. Following a brief introduction, the structures and properties of sulfoximines and metallated sulfoximines are discussed. The second section deals with the preparation of sulfoximines emphasising new methods. The main part of the review is concerned with reactions of sulfoximines. The material in this section is organised based on the reactivity pattern displayed by the various sulfoximines. Therefore they are grouped roughly into three classes of compounds. The first group of sulfoximines comprises compounds acting as C-nucleophiles, the second one contains electrophilic sulfoximines and the last group is made up of sulfoximines being useful as (chiral) ligands particularly for transition metals. Finally the ability of sulfoximines to act as "chiral chemical chameleons" and their rôle in biological and medicinal chemistry is briefly discussed.