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Synlett 1998; 1998(10): 1040-1044
DOI: 10.1055/s-1998-1854
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Inhibiting the Dimerization of HIV-1 Protease

Reena Zutshi* , Michael D. Shultz, Luckner Ulysse, Ray Lutgring, Patricia Bishop, Barbara Schweitzer, Karen Vogel, Jeff Franciskovich, Matt Wilson, Jean Chmielewski
  • *Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA; Fax 765 494 0239; E-mail: chml@chem.purdue.edu
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Publication Date:
28 January 2005 (online)

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Disrupting protein-protein interaction in multi-subunit enzymes is currently an underutilized mode of inhibition, and little information exists to assist the researcher in the design of agents to effect such a change within the enzyme. This work seeks to address these limitations by providing a general strategy for the design of dimerization inhibitors of the therapeutically significant enzyme HIV-1 protease.

dimeric - enzyme - inhibit - design

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