Enantioselective Addition of Diethylzinc to Aryl Aldehydes Catalyzed by ADPD Imine Catalysts
31 December 2000 (online)
The use of chiral imines 1-4 prepared from (4S,5S)-(+)-5-amino-2,2-dimethyl-4-phenyl-1,3-dioxane (ADPD) in the enantioselective addition of diethylzinc to aryl aldehydes is reported. Secondary aryl alcohols are obtained up to 85% ee in good yields.
(4S,5S)-(+)-5-amino-2,2-dimethyl-4-phenyl-1,3-dioxane - chiral imine - enantioselective addition - diethylzinc - titanium tetraisopropoxide