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Synlett 1998; 1998(9): 965-966
DOI: 10.1055/s-1998-1841
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Enantioselective Addition of Diethylzinc to Aryl Aldehydes Catalyzed by ADPD Imine Catalysts

Takashi Mino* , Katsuhiko Oishi, Masakazu Yamashita
  • *Department of Molecular Science and Technology, Faculty of Engineering, Doshisha University, Kyotanabe, Kyoto 610-0321, Japan; Fax 81-774-65-6840; E-mail: myamashi@mail.doshisha.ac.jp
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Publication Date:
31 December 2000 (online)

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The use of chiral imines 1-4 prepared from (4S,5S)-(+)-5-amino-2,2-dimethyl-4-phenyl-1,3-dioxane (ADPD) in the enantioselective addition of diethylzinc to aryl aldehydes is reported. Secondary aryl alcohols are obtained up to 85% ee in good yields.

(4S,5S)-(+)-5-amino-2,2-dimethyl-4-phenyl-1,3-dioxane - chiral imine - enantioselective addition - diethylzinc - titanium tetraisopropoxide

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