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Synthesis 1997; 1997(11): 1325-1330
DOI: 10.1055/s-1997-1340
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Diastereo- and Enantioselective Synthesis of Dimethylcyclohexanamines by Asymmetric Reductive Amination

B. Speckenback, P. Bisel, A. W. Frahm*
  • *Lehrstuhl für Pharmazeutische Chemie, Pharmazeutisches Institut, Hermann-Herder Straße 9, D-79104 Freiburg-im-Breisgau, Germany, Fax +49(761)2036351; E-mail: awfrahm@sun2.ruf.uni-freiburg.de
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Publikationsdatum:
31. Dezember 2000 (online)

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A series of optically active dimethylcyclohexanamines 6a-c, e, with ee values ranging from 86- >99%, have been synthesized by asymmetric reductive amination of the corresponding racemic diastereomeric cyclohexanones 3a-c, e. Their conformation and configuration are also discussed.

asymmetric reductive amination - dimethylcyclohexanamines - diastereo- and enantioselectivity - absolute configuration