Download PDF
Synthesis 1997; 1997(11): 1325-1330
DOI: 10.1055/s-1997-1340
paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Diastereo- and Enantioselective Synthesis of Dimethylcyclohexanamines by Asymmetric Reductive Amination

B. Speckenback, P. Bisel, A. W. Frahm*
  • *Lehrstuhl für Pharmazeutische Chemie, Pharmazeutisches Institut, Hermann-Herder Straße 9, D-79104 Freiburg-im-Breisgau, Germany, Fax +49(761)2036351; E-mail: awfrahm@sun2.ruf.uni-freiburg.de
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

A series of optically active dimethylcyclohexanamines 6a-c, e, with ee values ranging from 86- >99%, have been synthesized by asymmetric reductive amination of the corresponding racemic diastereomeric cyclohexanones 3a-c, e. Their conformation and configuration are also discussed.

asymmetric reductive amination - dimethylcyclohexanamines - diastereo- and enantioselectivity - absolute configuration

      >