PDF herunterladen
Synlett 1992; 1992(10): 791-792
DOI: 10.1055/s-1992-21491
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A Novel Method for the Coupling of Nucleoside Bases with Tetramethylene Sulphoxide

Ian A. O'Neil* , Kathryn M. Hamilton
  • *Robert Robinson Laboratories, Department of Chemistry, University of Liverpool, P.O. Box 147, Liverpool L69 3BX, England
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
08. März 2002 (online)

 als PDF herunterladen  Lizenzen und Reprints Alle Artikel dieser Rubrik

A silicon mediated Pummerer reaction for the coupling of nucleoside bases to a tetrahydrothiophene ring is described. Thus, treatment of the required base with TMS-triflate and triethylamine in toluene followed by the addition of tetramethylene sulphoxide and catalytic ZnI2 gave the requisite coupled product in moderate to good yield.