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Synlett 1992; 1992(10): 791-792
DOI: 10.1055/s-1992-21491
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A Novel Method for the Coupling of Nucleoside Bases with Tetramethylene Sulphoxide

Ian A. O'Neil* , Kathryn M. Hamilton
  • *Robert Robinson Laboratories, Department of Chemistry, University of Liverpool, P.O. Box 147, Liverpool L69 3BX, England
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Publication Date:
08 March 2002 (online)

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A silicon mediated Pummerer reaction for the coupling of nucleoside bases to a tetrahydrothiophene ring is described. Thus, treatment of the required base with TMS-triflate and triethylamine in toluene followed by the addition of tetramethylene sulphoxide and catalytic ZnI2 gave the requisite coupled product in moderate to good yield.

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