Nickel(0)-Mediated Intramolecular Cyclizations of Enynes, Dienynes, Bis-Dienes, and Diynes

Kohei Tamao; Kenji Kobayashi; Yoshihiko Ito

doi:10.1055/s-1992-21409

Synlett 1992; 1992(7): 539-546
DOI: 10.1055/s-1992-21409

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Nickel(0)-Mediated Intramolecular Cyclizations of Enynes, Dienynes, Bis-Dienes, and Diynes

Kohei Tamao^* , Kenji Kobayashi, Yoshihiko Ito

^*Department of Synthetic Chemistry, Faculty of Engineering, Kyoto University, Kyoto 606, Japan

Abstract

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Nickel(0)-mediated intramolecular cyclizations of enynes and diynes with isocyanides, "silylenes", and hydrosilanes have been found to be useful methods for the one-step synthesis of polycyclic compounds with functional groups, The article describes the following cyclization reactions and the properties, reactivities and synthetic utilities of new ring systems thus obtained. 1. Introduction 2. Cyclization of 1,n-Enynes, Dienynes, and 1,n-Diynes with Isocyanides 3. Cyclization of 1,7-Diynes and Bis-Dienes with Hydrosilanes 4. Cyclization of 1,6-Diynes with "Silylenes" 5. Conclusion

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