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Synlett 1992; 1992(3): 179-188
DOI: 10.1055/s-1992-21307
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C-5-Substituted Nucleoside Analogs

Don Bergstrom* , Xiaoping Lin, Guangyi Wang, David Rotstein, Peter Beal, Kathryn Norrix, Jerry Ruth
  • *Department of Medicinal Chemistry and Pharmacognosy, Purdue University, West Lafayette, Indiana 47907, USA
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Publikationsdatum:
08. März 2002 (online)

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Nucleosides modified at C-5 of the pyrimidine base have become important components of synthetic oligonucleotide probes. An account of how these compounds can be synthesized by way of palladium-mediated reactions is described. 1. Introduction 2. Palladium-Mediated Reactions of Alkenes with Mercurionucleosides 3. C-5 Substituted Nucleosides as Antiviral Agents 4. DNA Probes from Modified Nucleosides 5. Palladium-Mediated Reaction of Disulfides with Mercurionucleosides 6. Conclusion