Synthesis 1987; 1987(7): 589-603
DOI: 10.1055/s-1987-28019
review
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

α-Thioalkylation via Aldehydes and Thiols

D. James R. Massy*
  • *School of Chemical Sciences, University of East Anglia, Norwich NR4 7TJ, U. K.
Further Information

Publication History

Publication Date:
20 August 2002 (online)

Procedures for thioalkylation at carbon and at nitrogen are classified into six major types. These are discussed in relation to the principal substrates. In each area the most significant results are considered and commonly used methods of thioalkylation are exemplified. A brief account of some applications of thioalkylation in synthesis is presented. 1. Introduction 2. Terminology 3. Scope 4. Thioalkylation Routes 5. Mechanisms of Thioalkylation 6. Thioalkylation at Carbon 7. Thioalkylation at Nitrogen 8. Applications of Thioalkylation 9. Conclusions

    >