Synthesis 1969; 1969(3): 120-134
DOI: 10.1055/s-1969-34196
review
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Präparativ anwendbare mikrobiologische Reaktionen - Erster Teil. Allgemeine Arbeitsbedingungen, Oxidationsreaktionen

Klaus KIESLICH*
  • *Hauptlaboratorium der Schering AG, D-1 Berlin-West
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Publikationsdatum:
19. September 2002 (online)

The subject of microbiological reactions is not one of common knowledge to the organic chemist. The following review gives a brief introduction to the methods used in carrying out microbiological reactions and to their application to synthesis on a preparative scale. In order to demonstrate the usefulness of microbiological systems in laboratory chemistry, the review is limited to the discussion of enzymatic transformations in which a well-defined organic compound undergoes a defined reaction. Multistage biochemical processes such as alcoholic fermentation, which involve sequences of synthetic and degradative reactions, are not discussed. All of the examples quoted are submersion processes which give satisfactory yields of pure product. The review is publised in two parts: First part : General Remarks on Working Conditions (Cultures, Fermentation, Isolation of the Reaction Products) 1. Oxidations Second Part: 2. Reductions 3. Hydrolytic Reactions 4. Acylations and Condensations 5. Aminations 6. Decarboxylations

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