Appl Clin Inform 2022; 13(04): 891-900
DOI: 10.1055/s-0042-1756428
Research Article

Uncovering Discrepancies in IV Vancomycin Infusion Records between Pump Logs and EHR Documentation

Tsan-Hua Tung*
1   School of Industrial Engineering, College of Engineering, Purdue University, West Lafayette, Indiana, United States
Poching DeLaurentis**
2   Regenstrief Center for Healthcare Engineering, Purdue University, West Lafayette, Indiana, United States
Yuehwern Yih
1   School of Industrial Engineering, College of Engineering, Purdue University, West Lafayette, Indiana, United States
› Institutsangaben


Background Infusion start time, completion time, and interruptions are the key data points needed in both area under the concentration–time curve (AUC)- and trough-based vancomycin therapeutic drug monitoring (TDM). However, little is known about the accuracy of documented times of drug infusions compared with automated recorded events in the infusion pump system. A traditional approach of direct observations of infusion practice is resource intensive and impractical to scale. We need a new methodology to leverage the infusion pump event logs to understand the prevalence of timestamp discrepancies as documented in the electronic health records (EHRs).

Objectives We aimed to analyze timestamp discrepancies between EHR documentation (the information used for clinical decision making) and pump event logs (actual administration process) for vancomycin treatment as it may lead to suboptimal data used for therapeutic decisions.

Methods We used process mining to study the conformance between pump event logs and EHR data for a single hospital in the United States from July to December 2016. An algorithm was developed to link records belonging to the same infusions. We analyzed discrepancies in infusion start time, completion time, and interruptions.

Results Of the 1,858 infusions, 19.1% had infusion start time discrepancy more than ± 10 minutes. Of the 487 infusion interruptions, 2.5% lasted for more than 20 minutes before the infusion resumed. 24.2% (312 of 1,287) of 1-hour infusions and 32% (114 of 359) of 2-hour infusions had over 10-minute completion time discrepancy. We believe those discrepancies are inherent part of the current EHR documentation process commonly found in hospitals, not unique to the care facility under study.

Conclusion We demonstrated pump event logs and EHR data can be utilized to study time discrepancies in infusion administration at scale. Such discrepancy should be further investigated at different hospitals to address the prevalence of the problem and improvement effort.

Protection of Human and Animal Subjects

This research was conducted in compliance with the World Medical Association Declaration of Helsinki on Ethical Principles for Medical Research involving Human Subjects. All procedures were reviewed and approved by Purdue University Institutional Review Board (Protocol #1704019117).

* Tsan-Hua Tung, PhD, was at Purdue University at the time this study was conducted.

** Poching DeLaurentis, PhD, was in the Regenstrief Center for Healthcare Engineering at Purdue University in West Lafayette, IN, at the time this study was conducted.

Supplementary Material


Eingereicht: 13. April 2022

Angenommen: 29. Juli 2022

Artikel online veröffentlicht:
21. September 2022

© 2022. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany