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Synthesis 2024; 56(01): 47-54
DOI: 10.1055/s-0042-1751522
DOI: 10.1055/s-0042-1751522
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Rh(III)-Catalyzed Synthesis of Isocoumarins via C–H Activation of Phenacyl Phosphoniums with Iodonium Ylides
We gratefully acknowledge the National Natural Science Foundation of China (Project No. 21606080, 22071082), the Natural Science Foundation of Zhejiang Province (No. LY19B020004), the Jiaxing Key Laboratory for Creation of Animal Models and Synthesis of Lead Compounds of New Drug (No. JXSZ21002), and the Science and Technology Project of Jiaxing (No. 2022AY10018).

Abstract
A phosphonium-assisted C–H cyclization with iodonium ylides has been developed under redox-neutral rhodium(III) catalysis, offering a wide variety of valuable isocoumarins in moderate to good yields. This transformation proceeds through C–H activation, carbene insertion, and nucleophilic addition processes. The reaction occurs under a low catalyst loading in a short reaction time and does not require an oxidant.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0042-1751522.
- Supporting Information
- CIF File
Publication History
Received: 23 September 2023
Accepted after revision: 19 October 2023
Article published online:
23 November 2023
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