Synthesis 2020; 52(18): 2613-2622
DOI: 10.1055/s-0040-1707815
short review
© Georg Thieme Verlag Stuttgart · New York

Recent Advances on Copper-Catalyzed C–C Bond Formation via C–H Functionalization

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Leibniz Institute for Catalysis, Albert-Einstein-Str. 29a, 18059 Rostock, Germany   Email: [email protected]
› Author Affiliations
Financial support by the Deutscher Akademischer Austauschdienst (DAAD) (German Academic Exchange Service) (Leadership for Syria Program) is gratefully acknowledged.
Further Information

Publication History

Received: 14 February 2020

Accepted after revision: 28 April 2020

Publication Date:
19 May 2020 (online)


Abstract

Reactions that form C–C bonds are at the heart of many important transformations, both in industry and in academia. From the myriad of catalytic approaches to achieve such transformations, those relying on C–H functionalization are gaining increasing interest due to their inherent sustainable nature. In this short review, we showcase the most recent advances in the field of C–C bond formation via C–H functionalization, but focusing only on those methodologies relying on copper catalysts. This coinage metal has gained increased popularity in recent years, not only because it is cheaper and more abundant than precious metals, but also thanks to its rich and versatile chemistry.

1 Introduction

2 Cross-Dehydrogenative Coupling under Thermal Conditions

2.1 C(sp3)–C(sp3) Bond Formation

2.2 C(sp3)–C(sp2) Bond Formation

2.3 C(sp2)–C(sp2) Bond Formation

2.4 C(sp3)–C(sp) Bond Formation

3 Cross-Dehydrogenative Coupling under Photochemical Conditions

3.1 C(sp3)–C(sp3) Bond Formation

3.2 C(sp3)–C(sp2) and C(sp3)–C(sp) Bond Formation

4 Conclusion and Perspective

 
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