Synthesis 2020; 52(20): 2948-2961
DOI: 10.1055/s-0040-1707210
short review
© Georg Thieme Verlag Stuttgart · New York

Biocatalytic and Chemo-Enzymatic Approaches for the Synthesis of Heterocycles

Fei Zhao
,
Domiziana Masci
,
Elena Tomarelli
,
School of Cancer and Pharmaceutical Sciences, King’s College London, 150 Stamford Street, London, SE1 9NH, UK   Email: daniele.castagnolo@kcl.ac.uk
› Author Affiliations
Financial support from the Mobility Projects Call for Research Doctorates (Grant No. 2682), the K. C. Wong Education Foundation (fellowship to F.Z.) is gratefully acknowledged.
Further Information

Publication History

Received: 01 June 2020

Accepted: 22 June 2020

Publication Date:
28 July 2020 (online)


Abstract

Heterocycles are ubiquitous structures in nature and can be found in many drugs and chemicals. Biocatalysts, alone or in combination with other metal catalysts, can be exploited for the construction of various heterocyclic rings under mild reaction conditions. This Short Review highlights the recent advances in the development of biocatalytic and chemo-enzymatic methods for the synthesis of both aliphatic and aromatic heterocyclic rings.

1 Introduction

2 Synthesis of Aliphatic Heterocycles

2.1 Piperidines, Pyrrolidines and Piperazines

2.2 Other Nitrogen-Containing Aliphatic Heterocycles

2.3 Lactones and Lactams

2.4 Other Oxygen-Containing Heterocycles

3 Synthesis of Aromatic Heterocycles

3.1 Pyrroles, Pyridines and Pyrazines

3.2 Furans

3.3 Bicyclic Aromatic Heterocycles

4 Conclusion

 
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