Synthesis 2020; 52(23): 3530-3548
DOI: 10.1055/s-0040-1707208
short review
© Georg Thieme Verlag Stuttgart · New York

Recent Advances in the Synthesis and Applications of 2-Arylbenzothiazoles

Fuqiang Gan
a  Department of Obstetrics and Gynecology, Jiangxi Provincial People’s Hospital, 92 Aiguo Road, Nanchang, Jiangxi 330006, P. R. of China   Email: [email protected]
,
Puying Luo
a  Department of Obstetrics and Gynecology, Jiangxi Provincial People’s Hospital, 92 Aiguo Road, Nanchang, Jiangxi 330006, P. R. of China   Email: [email protected]
,
Junyue Lin
b  Key Laboratory of Functional Small Organic Molecule, Ministry of Education and Jiangxi's Key Laboratory of Green Chemistry, Jiangxi Normal University, 99 Ziyang Road, Nanchang, Jiangxi 330022, P. R. of China
c  College of Chemistry & Chemical Engineering, Jinganshan University, Xueyuan Road, Ji’an, Jiangxi 343009, P. R. of China
,
Qiuping Ding
b  Key Laboratory of Functional Small Organic Molecule, Ministry of Education and Jiangxi's Key Laboratory of Green Chemistry, Jiangxi Normal University, 99 Ziyang Road, Nanchang, Jiangxi 330022, P. R. of China
› Author Affiliations
Financial support from the National Natural Science Foundation of China (21662017, 21961016), and Jiangxi Health and Family Planning Commission Project (20161015) is gratefully acknowledged.
Further Information

Publication History

Received: 19 May 2020

Accepted after revision: 15 June 2020

Publication Date:
05 August 2020 (online)


Abstract

This review firstly covers the applications of 2-arylbenzothiazoles as amyloid imaging agents, antitumor agents, and organic luminescent materials. Then we review the recent advances in the synthesis of 2-arylbenzothiazole derivatives. On the one hand, we introduce the approaches for construction of the 2-arylbenzothiazole core, including the following categories: (i) classic condensation of 2-aminothiophenols, (ii) direct arylation of benzothiazoles, (iii) intramolecular cyclization of thiobenzanilides, and (iv) tandem cyclization of anilines/ nitroarenes­ with elemental sulfur or sulfides. On the other hand, the transition-metal-catalyzed direct C–H functionalizations of 2-aryl­benzothiazoles are also involved in this review.

1 Introduction

2 Applications of 2-Arylbenzothiazoles

3 Construction of the 2-Arylbenzothiazole Core

4 Synthesis 2-Arylbenzothiazoles via Direct C–H Functionalization

5 Conclusion

 
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