Leveraging Framework Instability: A Journey from Energy Storage to Drug Delivery

Kuthuru Suresh; Vilmalí López-Mejías; Saikat Roy; Daniel F. Camacho; Adam J. Matzger

doi:10.1055/s-0040-1707139

Synlett, Inhaltsverzeichnis

Synlett 2020; 31(16): 1573-1580
DOI: 10.1055/s-0040-1707139

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Leveraging Framework Instability: A Journey from Energy Storage to Drug Delivery

Authors

Kuthuru Suresh

^aDepartment of Chemistry, University of Michigan, Ann Arbor, MI 48109-1055, USA
Vilmalí López-Mejías

^aDepartment of Chemistry, University of Michigan, Ann Arbor, MI 48109-1055, USA
Saikat Roy

^aDepartment of Chemistry, University of Michigan, Ann Arbor, MI 48109-1055, USA
Daniel F. Camacho

^aDepartment of Chemistry, University of Michigan, Ann Arbor, MI 48109-1055, USA
Adam J. Matzger ∗

^aDepartment of Chemistry, University of Michigan, Ann Arbor, MI 48109-1055, USA

^bMacromolecular Science and Engineering, University of Michigan, Ann Arbor, MI 48109-1055, USA eMail: matzger@umich.edu

Abstract

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Abstract

Amorphous pharmaceuticals often suffer from poor physical stability, which can negate their high solubility, fast dissolution rate, and better oral bioavailability vs. crystalline forms. This represents a major hurdle to processing, storage, and delivery of amorphous pharmaceuticals. Several approaches to addressing these problems have been pursued, but there is still a need for a general method for stabilizing the amorphous form. We describe a novel approach using a water-unstable metal-organic framework as a drug delivery vehicle that demonstrates improved amorphous form stability accompanied by remarkably enhanced solubility and a fast dissolution rate. This research project spanned eleven years from conception to realization and dissemination. With origins in understanding the stability or porous solids for energy storage materials, the work also highlights potential of basic science understanding to illuminate new areas of application.

Key words

pharmaceuticals - amorphous form - metal-organic frameworks - stability - solubility and dissolution rate

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Referenzen

References and Notes

Current addresses:

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1b Innovation Centre, Tata Chemicals Ltd, Ambedveth, Pune, Maharashtra, 412111, India.
1c Pritzker School of Medicine, University of Chicago, Chicago, IL, USA.

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