Published as part of the Special Topic Recent Advances in Amide Bond Formation
Abstract
Owing to the inherent ability of amides to chelate transition-metal catalysts, amide-directed
C–H activation reactions constitute a major tactic in directed C–H activation reactions.
While the conventional procedures for these reactions usually involve prior preparation
and purification of amide substrates before the C–H activation, the step economy is
actually undermined by the operation of installing the directing group (DG) and related
substrate purification. In this context, directed C–H activation via in situ amidation
of the crude material provides a new protocol that can significantly enhance the step
economy of amide-directed C–H activation. In this short review, the advances in C–H
bond activation reactions mediated or initiated by in situ amidation are summarized
and analyzed.
1 Introduction
2 In Situ Amidation in Aryl C–H Bond Activation
3 In Situ Amidation in Alkyl C–H Bond Activation
4 Annulation Reactions via Amidation-Mediated C–H Activation
5 Remote C–H Activation Mediated by Amidation
6 Conclusion
Key words
tandem reactions - amidation - C–H activation - step economy - one-pot