Synthesis 2021; 53(06): 1061-1076
DOI: 10.1055/s-0040-1706146
short review

Alkylzirconocenes in Organic Synthesis: An Overview

Chao Yang
a  School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, P. R. of China
b  National Institute of Biological Sciences, 7 Science Park Road, Zhongguancun Life Science Park, Beijing 102206, P. R. of China
,
Chao Jiang
a  School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, P. R. of China
,
b  National Institute of Biological Sciences, 7 Science Park Road, Zhongguancun Life Science Park, Beijing 102206, P. R. of China
c  Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 100084, P. R. of China
› Author Affiliations
This work was supported by the Ministry of Science and Technology of the People’s Republic of China (Grant No. 2014CB849603), the National­ Natural Science Foundation of China (NSFC) (Grant No. 21772092) and the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD), China.


Abstract

Organozirconium chemistry has found extensive applications in organic synthesis since its discovery in the last century. Alkyl­zirconocenes, which are easily generated by the hydrozirconation of alkenes with the Schwartz reagent, are widely utilized for carbon–carbon­ and carbon–heteroatom bond formation. This short review summarizes the progress to date on the applications alkylzirconocenes in organic synthesis.

1 Introduction

2 General Methods for Generating Alkylzirconocenes

3 Transformations of Alkylzirconocenes by Heteroatoms

4 Insertion of Unsaturated Groups into Alkylzirconocenes

5 Transmetalations

6 Cross-Coupling Reactions of Alkylzirconocenes

7 Photochemistry of Alkylzirconocenes

8 Bimetallic Reagents of Zirconium

9 Asymmetric Transformations

10 Applications of Alkylzirconocenes Generated from the Negishi Reagent

11 Conclusions and Outlook



Publication History

Received: 04 November 2020

Accepted after revision: 11 January 2021

Publication Date:
11 February 2021 (online)

© 2021. Thieme. All rights reserved

Georg Thieme Verlag KG
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