Synthesis 2021; 53(05): 925-932
DOI: 10.1055/s-0040-1706087
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A Catalytic One-Pot Synthesis of Indolyl Cyclobutanones

Stefania Porcu
,
Carla Aira Rodriguez
,
,
We gratefully acknowledge funding from the Fondazione di Sardegna (CUP F71I17000180002).


Abstract

A general strategy for the synthesis of indolyl cyclobutanones via a tandem Brønsted acid catalyzed 2-hydroxycyclobutanone activation–indole nucleophilic addition has been exploited. The procedure leads to a wide range of 2- and 3-functionalized indole derivatives in good to high yields with broad substrate scope.

Supporting Information



Publication History

Received: 14 September 2020

Accepted after revision: 30 October 2020

Publication Date:
03 December 2020 (online)

© 2020. Thieme. All rights reserved

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
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