A Catalytic One-Pot Synthesis of Indolyl Cyclobutanones

Abstract

A general strategy for the synthesis of indolyl cyclobutanones via a tandem Brønsted acid catalyzed 2-hydroxycyclobutanone activation–indole nucleophilic addition has been exploited. The procedure leads to a wide range of 2- and 3-functionalized indole derivatives in good to high yields with broad substrate scope.

Key words

indoles - cyclobutanones - Brønsted acids - tandem reactions - catalysis

Publikationsverlauf

Eingereicht: 14. September 2020

Angenommen nach Revision: 30. Oktober 2020

Artikel online veröffentlicht:
03. Dezember 2020

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