Synthesis 2021; 53(06): 1046-1060
DOI: 10.1055/s-0040-1705996
short review

Gold Catalysis and Furans: A Powerful Match for Synthetic Connections

Stefano Nejrotti
,
Cristina Prandi
We thank the Italian Ministery of Research, the Cassa di Risparmio of Turin and Huvepharma srl for funding.


Abstract

This review summarizes the advances made on the synthesis and functionalization of furans via gold catalysis during the period between 2016 and 2020. A separate section is dedicated to the tandem gold-catalyzed synthesis and functionalization of furans.

1 Introduction

2 Gold-Catalyzed Synthesis of Furans

2.1 Cycloisomerizations of Alkynyl and Cumulenyl Alcohols

2.2 Cycloisomerizations of Alkynyl and Allenyl Ketones

2.3 Reactions with External Oxidants

2.4 Miscellaneous

3 Gold-Catalyzed Functionalization of Furans

3.1 Cycloadditions

3.2 Furan Ring Decorations

3.3 Reactions Involving Furan Ring Opening

4 Gold-Catalyzed Tandem Synthesis and Functionalization of Furans­

4.1 Cycloisomerizations Followed by Gold-Catalyzed Cycloaddition

4.2 Cycloisomerizations to a Gold 1,3- or 1,4-Dipole and Intermolecular Annulation

4.3 Cycloisomerizations to a Gold Carbene and Intermolecular Trapping

5 Conclusion



Publication History

Received: 05 October 2020

Accepted after revision: 05 November 2020

Publication Date:
21 December 2020 (online)

© 2020. Thieme. All rights reserved

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
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