Recent Advances in Difluoromethylthiolation

Xuan Xiao; Zi-Tong Zheng; Ting Li; Jing-Lin Zheng; Ting Tao; Li-Mei Chen; Jin-Ying Gu; Xu Yao; Jin-Hong Lin; Ji-Chang Xiao

doi:10.1055/s-0039-1690714

Synthesis, Inhaltsverzeichnis

Synthesis 2020; 52(02): 197-207
DOI: 10.1055/s-0039-1690714

short review

Recent Advances in Difluoromethylthiolation

Xuan Xiao §

^aGroup of Lead Compound, Institute of Pharmacy & Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, P. R. of China eMail: yaoyao19840415@126.com

^bKey Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200032, P. R. of China eMail: jlin@sioc.ac.cn eMail: jchxiao@sioc.ac.cn

,

Zi-Tong Zheng §

^aGroup of Lead Compound, Institute of Pharmacy & Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, P. R. of China eMail: yaoyao19840415@126.com

,

Ting Li

^aGroup of Lead Compound, Institute of Pharmacy & Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, P. R. of China eMail: yaoyao19840415@126.com

,

Jing-Lin Zheng

^aGroup of Lead Compound, Institute of Pharmacy & Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, P. R. of China eMail: yaoyao19840415@126.com

,

Ting Tao

^aGroup of Lead Compound, Institute of Pharmacy & Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, P. R. of China eMail: yaoyao19840415@126.com

,

Li-Mei Chen

^aGroup of Lead Compound, Institute of Pharmacy & Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, P. R. of China eMail: yaoyao19840415@126.com

,

Jin-Ying Gu

^aGroup of Lead Compound, Institute of Pharmacy & Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, P. R. of China eMail: yaoyao19840415@126.com

,

Xu Yao∗

^aGroup of Lead Compound, Institute of Pharmacy & Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, P. R. of China eMail: yaoyao19840415@126.com

,

Jin-Hong Lin∗

^bKey Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200032, P. R. of China eMail: jlin@sioc.ac.cn eMail: jchxiao@sioc.ac.cn

,

Ji-Chang Xiao∗

^bKey Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200032, P. R. of China eMail: jlin@sioc.ac.cn eMail: jchxiao@sioc.ac.cn

› Institutsangaben

Abstract

Alle Artikel dieser Rubrik

^§ These authors contributed equally to this work.

Abstract

The difluoromethylthio group (HCF₂S), which has been identified as a valuable functionality in drug and agrochemical discovery, has received increased attention recently. Two strategies, difluoromethylation and direct difluoromethylthiolation, have been well established for HCF₂S incorporation. The former strategy suffers from the need to prepare sulfur-containing substrates. In contrast, direct difluoromethylthiolation is straightforward and step-economic. This short review covers the recent advances in direct difluoromethylthiolation, including electrophilic, radical, and transition-metal-catalyzed or -promoted reactions.

1 Introduction

2 Electrophilic Difluoromethylthiolation

3 Radical Difluoromethylthiolation

4 Transition-Metal-Catalyzed or -Promoted Difluoromethylthiolation

5 Conclusions and Perspectives

Key words

difluoromethylthio group - difluoromethylthiolation - electrophilic - radical - fluorine

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Referenzen

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