Synthesis 2020; 52(01): 1-20
DOI: 10.1055/s-0039-1690684
review
© Georg Thieme Verlag Stuttgart · New York

Recent Advances in Reactions of Propargylamines

Xia Sheng
,
Kaijun Chen
,
Chengjin Shi
,
Department of Chemistry, Lishui University, No. 1, Xueyuan Road, Lishui City 323000, Zhejiang Province, P. R. of China   Email: dayunhuang@lsu.edu.cn
› Author Affiliations
We thank the Natural Science Foundation of Zhejiang Province (LQ18B020001) for financial support.
Further Information

Publication History

Received: 16 July 2019

Accepted after revision: 02 September 2019

Publication Date:
08 October 2019 (online)


These authors contributed equally.

Abstract

Propargylamines are extremely versatile and common building blocks in the field of chemistry. This review highlights the recent advances made in the reactions of propargylamines between 2009 and 2019. The reaction types are classified into six categories based on the trigger mechanisms: (1) amino moieties as leaving groups, (2) hydrogenation, (3) rearrangement, (4) nucleophilic amines, (5) nucleophilic carbons, and (6) electrophilic alkynes. We hope that this review will promote future research in this area.

1 Introduction

2 Amino Moieties as Leaving Groups

3 Hydrogenation

4 Rearrangement

5 Nucleophilic Amines

6 Nucleophilic Carbons

7 Electrophilic Alkynes

8 Conclusions

 
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