Hydroalkylation of Unactivated Alkenes with Ketones and 5-Benzylfurfurals Enabled by Amine/Pd(II) Cooperative Catalysis

^§ M. Sayed and H.-C. Shen contributed equally to this manuscript

Abstract

An intermolecular addition of ketones to unactivated alkenes has been developed by means of Pd(II)/amine cooperative catalysis, which incorporates the simultaneous activation of amide-containing alkenes and α-carbon of ketones enabled by Pd(II) catalyst and enamine, respectively. Moreover, the addition of 5-benzylfurfural derivatives to an unactivated alkene has also been achieved by integrating Pd(II) and trienamine catalysis to provide γ-adducts at the benzylic position of furfurals in good to high yields.

Key words

alkene - ketones - 5-benzylfurfurals - hydroalkylation - co­operative catalysis

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