Synthesis 2020; 52(11): 1602-1616
DOI: 10.1055/s-0039-1690089
short review
© Georg Thieme Verlag Stuttgart · New York

Functionalised Nitrogen Heterocycles and the Search for New Antibacterials and Bioactives

Muhammad Kamran Khan
a  Oxford Suzhou Centre for Advanced Research, Building A, 388 Ruo Shui Road, Suzhou Industrial Park, Jiangsu, 215123, P. R. of China
,
Dandan Wang
a  Oxford Suzhou Centre for Advanced Research, Building A, 388 Ruo Shui Road, Suzhou Industrial Park, Jiangsu, 215123, P. R. of China
,
Mark G. Moloney
a  Oxford Suzhou Centre for Advanced Research, Building A, 388 Ruo Shui Road, Suzhou Industrial Park, Jiangsu, 215123, P. R. of China
b  The Department of Chemistry, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA,    Email: mark.moloney@chem.ox.ac.uk
› Author Affiliations
Further Information

Publication History

Received: 27 January 2020

Accepted: 26 February 2020

Publication Date:
30 March 2020 (online)


Abstract

The importance of, and synthetic routes to, pyrrolidines and piperidines, along with their relevance to natural product synthesis and antibacterial drug discovery, are surveyed in the context of an extended programme of investigation from our own laboratories.

1 Introduction

2 Pyroglutamates

2.1 Synthesised by Modification of an Existing Ring

2.2 Synthesised by Construction of a New Ring

3 Tetramates

4 Metal Chelation

5 Biological Activity

6 Conclusion

 
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