Synlett 2019; 30(13): 1525-1535
DOI: 10.1055/s-0037-1611861
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© Georg Thieme Verlag Stuttgart · New York

Electrophilic Amination: An Update

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Department of Chemistry, Rice University, BioScience Research Collaborative, 6500 Main Street, Houston, TX 77030, USA   Email: kurti.laszlo@rice.edu
› Author Affiliations
We thank the National Institute of General Medical Sciences (R01 GM-114609-04), the National Science Foundation (CAREER:SusChEM CHE-1546097) and the Robert A. Welch Foundation (Grant C-1764) for financial support. L.K. gratefully acknowledges the generous financial support of Rice University.
Further Information

Publication History

Received: 23 April 2019

Accepted after revision: 20 May 2019

Publication Date:
08 July 2019 (eFirst)

Abstract

In this account, we provide an overview of some recent advances in electrophilic amination methodologies that have been developed in the Kürti group over the last seven years. Our group’s focus has been to develop novel amination methodologies that directly yield N-unprotected amine products.

1 Introduction

2 Amination of Boronic Acids

3 Aziridination of Unactivated Olefins

4 Rhodium-Catalyzed C–H Amination of Arenes

5 Synthesis of Carbazoles

6 Amination of Aryl- and Alkylmetals

7 Doubly Electrophilic N-Linchpin Reagents

8 Aza-Rubottom Oxidation of Silyl Enol Ethers

9 Summary

 
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