Synthesis 2019; 51(15): 2891-2896
DOI: 10.1055/s-0037-1611836
psp
© Georg Thieme Verlag Stuttgart · New York

Synthesis of N-Pyridyl Hydroxylamines via Copper-Catalyzed Cross-Coupling

Carilyn Torruellas*
CCDC Chemical Biological Center, 8198 Blackhawk Rd., Aberdeen Proving Ground, MD 21010, United States   Email: [email protected]
,
Fu-Lian Hsu
,
Andrew J. Walz
› Author Affiliations
U.S. Defense Threat Reduction Agency Joint Science and Technology Office (DTRA-JSTO, CB10243) is acknowledged for the financial support.
Further Information

Publication History

Received: 21 March 2019

Accepted after revision: 26 April 2019

Publication Date:
15 May 2019 (online)


Abstract

N-Pyridyl hydroxylamine derivatives were prepared via copper-catalyzed cross-coupling of orthogonally functionalized hydroxylamines with iodopyridines. Various amino- and hydroxyl-protecting groups were tolerated. A total of 20 examples were synthesized in 28–90% yield.

Supporting Information

 
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