Synthesis 2019; 51(11): 2252-2260
DOI: 10.1055/s-0037-1611796
short review
© Georg Thieme Verlag Stuttgart · New York

The Chemical Syntheses of Nannocystins

University at Albany, State University of New York, 1400 Washington Ave., Albany, NY 12222, USA   eMail: zwang9@albany.edu
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Start-up funds from SUNY-Albany are greatly acknowledged.
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Publikationsverlauf

Received: 12. März 2019

Accepted after revision: 21. März 2019

Publikationsdatum:
17. April 2019 (online)


Abstract

The broad and potent anticancer activity of the nannocystin family of natural products has attracted significant efforts toward their total syntheses. Currently, seven total syntheses of different members of the nannocystins have been reported. In this Short Review, different synthetic approaches are highlighted. The reported structure-activity relationship (SAR) studies will also be highlighted.