Synthesis 2019; 51(12): 2491-2505
DOI: 10.1055/s-0037-1611524
special topic
© Georg Thieme Verlag Stuttgart · New York

Ruthenium-Catalyzed Selective Reduction of Carboxylic Esters and Carboxamides

Yongyun Zhou
a  YMU-HKBU Joint Laboratory of Traditional Natural Medicine, Yunnan Minzu University, Kunming 650504, P. R. of China   Email: adams.bmf@hotmail.com
,
a  YMU-HKBU Joint Laboratory of Traditional Natural Medicine, Yunnan Minzu University, Kunming 650504, P. R. of China   Email: adams.bmf@hotmail.com
,
a  YMU-HKBU Joint Laboratory of Traditional Natural Medicine, Yunnan Minzu University, Kunming 650504, P. R. of China   Email: adams.bmf@hotmail.com
,
Lijin Xu*
b  Department of Chemistry, Renmin University of China, Beijing 100872, P. R. of China   Email: 20050062@ruc.edu.cn
› Author Affiliations
We are grateful to the National Natural Science Foundation of China (21572198, 21372258) and the Applied Basic Research Foundation of Yunnan Province (2017FA004, 2018FB021), and Yunnan Provincial Key Laboratory Construction Plan Funding of Universities for their financial support.
Further Information

Publication History

Received: 08 March 2019

Accepted after revision: 29 March 2019

Publication Date:
30 April 2019 (eFirst)

Published as part of the Special Topic Ruthenium in Organic Synthesis

Abstract

Amines and alcohols are important classes of building blocks in organic synthesis. The synthesis of these compounds has been a topic of interest. A straightforward method for their synthesis is the reduction of esters and amides to alcohols and amines, respectively. Various transition-metal catalysts have been developed for the homogeneous hydrogenation of esters and amides to alcohols and amines. In this review, an overview of the ruthenium-catalyzed selective hydrogenation of esters and amides is provided.

1 General Introduction

2 Ru-Catalyzed Reduction of Esters

3 Ru-Catalyzed Selective Reduction of Amides

4 Conclusions

 
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