Recent Advances in the Total Synthesis of Clavaminols

Tian Jin; Lu Zhao; Xiao Liu; Liang Sun; Jia-Fu Lin; Zhe-Bin Zheng

doi:10.1055/s-0037-1610305

Synthesis, Table of Contents

Synthesis 2018; 50(23): 4569-4576
DOI: 10.1055/s-0037-1610305

short review

Recent Advances in the Total Synthesis of Clavaminols

Authors

Tian Jin*

^aKey Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu 610052, P. R. of China Email: jintian@cdu.edu.cn Email: zhebinzheng@hotmail.com
Lu Zhao*

^bSichuan Institute for Food and Drug Control, Chengdu 611731, P. R. of China Email: zhaolu0309@126.com
Xiao Liu

^aKey Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu 610052, P. R. of China Email: jintian@cdu.edu.cn Email: zhebinzheng@hotmail.com
Liang Sun

^cDepartment of Pharmacy, Jilin Province People’s Hospital, Changchun 130021, P. R. of China
Jia-Fu Lin

^aKey Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu 610052, P. R. of China Email: jintian@cdu.edu.cn Email: zhebinzheng@hotmail.com
Zhe-Bin Zheng*

^aKey Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu 610052, P. R. of China Email: jintian@cdu.edu.cn Email: zhebinzheng@hotmail.com

Abstract

All articles of this category

Abstract

Clavaminols are a new class of long-chain 2-amino-3-alkanols that mostly contain 2R,3S-configurations. Owing to their interesting molecular architectures and promising activities, they have become popular targets for synthetic organic chemists. In this review, we highlight 12 total syntheses of clavaminols from different research groups during the period 2009 to 2018.

1 Introduction

2 Synthetic Approaches toward Clavaminols

2.1 Total Synthesis by Chemla and Colleagues (2009)

2.2 Total Synthesis by Greck and Colleagues (2010)

2.3 Total Synthesis by Sutherland and Zaed (2011)

2.4 Total Synthesis by Huang and Colleagues (2011)

2.5 Total Synthesis by Kotora and Colleagues (2012)

2.6 Total Synthesis by Kumar and Colleagues (2013)

2.7 Total Synthesis by Prabhavathi Devi and Colleagues (2013 and 2016)

2.8 Total Synthesis by Sarabia and Colleagues (2014)

2.9 Total Synthesis by Mohapatra and Colleagues (2016)

2.10 Total Synthesis by Lu and Colleagues (2016)

2.11 Total Synthesis by Jin and Colleagues (2017)

2.12 Total Synthesis by Kumar Pandey and Colleagues (2018)

3 Conclusion

Key words

total synthesis - clavaminols - natural products - long-chain 2-amino-3-alkanols - antitumor activity

Full Text

References

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