Synthesis 2018; 50(17): 3346-3358
DOI: 10.1055/s-0037-1610085
special topic
© Georg Thieme Verlag Stuttgart · New York

Recent Developments in Visible-Light-Catalyzed Multicomponent Trifluoromethylation of Unsaturated Carbon–Carbon Bonds

Eun Hye Oh
a  Division of Bio and Drug Discovery, Korea Research Institute of Chemical Technology, 141 Gajeongro, Yuseong, Daejeon, 34113, Republic of Korea   Email: sbhan@krict.re.kr
b  Department of Chemistry, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02481, Republic of Korea
,
Hyun Jin Kim*
a  Division of Bio and Drug Discovery, Korea Research Institute of Chemical Technology, 141 Gajeongro, Yuseong, Daejeon, 34113, Republic of Korea   Email: sbhan@krict.re.kr
,
a  Division of Bio and Drug Discovery, Korea Research Institute of Chemical Technology, 141 Gajeongro, Yuseong, Daejeon, 34113, Republic of Korea   Email: sbhan@krict.re.kr
c  Department of Medicinal and Pharmaceutical Chemistry, University of Science and Technology, 217 Gajeongro, Yuseong, Daejeon, 34113, Republic of Korea
› Author Affiliations
This work was supported by Korea Research Institute of Chemical Technology (Grant No. KK 1803-C00, KK 1803-B01 and BS.K18M101)
Further Information

Publication History

Received: 16 April 2018

Accepted after revision: 02 May 2018

Publication Date:
16 July 2018 (eFirst)

Published as part of the Special Topic Photoredox Methods and their Strategic Applications in Synthesis

Abstract

Trifluoromethylation has emerged as an important tool for modulating the molecular chemical and physical properties in material, polymer, and medicinal chemistry. In particular, photocatalyzed trifluoromethylation in the presence of visible-light irradiation has potentially different activity under mild conditions compared with traditional methods. This review summarizes the recent advances in trifluoromethylation with multiple bond system such as alkynes and alkenes.

1 Introduction

2 Trifluoromethylating Reagents

3 Multicomponent Reactions of Alkynes

4 Multicomponent Reactions of Alkenes

5 Conclusion

 
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