Photoredox-Catalyzed Radical Relay Reaction Toward Functionalized Vicinal Diamines

Xiao-De An; Shouyun Yu

doi:10.1055/s-0037-1609844

Synthesis, Table of Contents

Synthesis 2018; 50(17): 3387-3394
DOI: 10.1055/s-0037-1609844

special topic

Photoredox-Catalyzed Radical Relay Reaction Toward Functionalized Vicinal Diamines

Xiao-De An

State Key Laboratory of Analytical Chemistry for Life Science, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China Email: yushouyun@nju.edu.cn

,

Shouyun Yu *

State Key Laboratory of Analytical Chemistry for Life Science, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China Email: yushouyun@nju.edu.cn

› Author Affiliations

Abstract

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Published as part of the Special Topic Photoredox Methods and their Strategic Applications in Synthesis

Abstract

A strategy has been described to synthesize β,γ-diaminoketones. This strategy is enabled by photoredox-catalyzed and nitrogen-centered radical-triggered cascade reactions of styrenes, enamides, and O-acylhydroxylamines in DMSO. Four bonds (one C–C, one C–N, and two C–O) are constructed in a single operation. Various functionalized vicinal diamines have been furnished by the radical relay reaction.

Key words

photochemistry - ketones - nitrogen-centered radicals - cascade reactions - vicinal diamines

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References

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