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Synthesis 2018; 50(02): 349-360
DOI: 10.1055/s-0036-1591487
DOI: 10.1055/s-0036-1591487
paper
Catalyst-Free Regioselective Nazarov Cyclization of Aryl Allenyl Ketones
Autor*innen
We are grateful to the National Natural Science Foundation of China (21302169), the Natural Science Foundation of Zhejiang Province (LQ16B020001), the Science Foundation of Zhejiang Sci-Tech University (13062121-Y), and the Program for Innovative Research Team of Zhejiang Sci-Tech University (13060052-Y) for financial support.
Weitere Informationen
Publikationsverlauf
Received: 03. August 2017
Accepted after revision: 13. September 2017
Publikationsdatum:
09. Oktober 2017 (online)
Abstract
The catalyst-free Nazarov cyclization of aryl allenyl ketones under thermal condition is developed. Various densely functionalized 2,3-dihydroindanones or indenones are readily produced in moderate to excellent yields. Significantly, this procedure features high functional group tolerance and exclusive regioselectivity. The resulting substituted 2,3-dihydroindanones can be conveniently converted into valuable conjugated benzofulvene building blocks.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1591487.
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