Synthesis 2017; 49(18): 4111-4123
DOI: 10.1055/s-0036-1590966
short review
© Georg Thieme Verlag Stuttgart · New York

Axially Chiral Shape-Persistent Encapsulating Agents

Sandra Míguez-Lago, María Magdalena Cid*
  • Departamento de Química Orgánica, Universidade de Vigo, Edificio de Ciencias Experimentais, Campus Lagoas-Marcosende, Vigo, 36310, Spain   Email: mcid@uvigo.es   Email: sandra.miguez@uvigo.es
Financial support from Spanish Government and Xunta de Galicia is acknowledged (CTQ2014-58629-R and GPC2014/066, respectively).
Further Information

Publication History

Received: 15 May 2017

Accepted after revision: 26 June 2017

Publication Date:
11 August 2017 (eFirst)

Abstract

In this review is presented the results of investigations during the last two decades on molecular recognition processes, mainly chiral host–guest systems insofar as they deal with intermolecular recognition events. Attention is devoted to those systems involving chiral hosts whose chirality does not arise from the presence of a chiral center and that possess a defined cavity to accommodate guests. Thus, the scope of this short review is restricted to chiral containers in which size, shape, and functionality are critical aspects, while those examples involving chirality transfer processes are excluded. The systems covered are those with axial chirality, including helical chirality, in which the chirality, that can be inherent or induced by steric interactions, originates from the 3D helical array of substituents. More specifically, the focus is on both macrocycles that bear open cavities and molecular cages with more enclosed voids.

1 Introduction

2 Encapsulating Agents: Macrocycles

3 Encapsulating Agents: Molecular Cages

4 Conclusions