Vinylation of Iododifluoromethylated Alcohols via a Light-Promoted Intramolecular Atom-Transfer ReactionThis work was supported by the Russian Science Foundation (project 17-13-01041).
Received: 16 May 2017
Accepted after revision: 06 July 2017
07 August 2017 (eFirst)
A method for the synthesis of gem-difluorohomoallylic alcohols by the substitution of iodine in the iododifluoromethyl group by a vinyl fragment is described. The reaction proceeds via an intramolecular iodine atom transfer followed by β-elimination. The reaction is performed in the presence of an iridium photocatalyst, fac-Ir(ppy)3, and triphenylphosphine under irradiation with light-emitting diodes.