Synthesis 2017; 49(17): 3957-3961
DOI: 10.1055/s-0036-1589064
special topic
© Georg Thieme Verlag Stuttgart · New York

A Simple Cobalt(II) Chloride Catalyzed N-Alkylation of Amines with Alcohols

Siba P. Midya
a  Catalysis Division, Dr. Homi Bhabha Road, CSIR-National Chemical Laboratory (CSIR-NCL), Pune 411008, India
b  Academy of Scientific and Innovative Research (AcSIR), New Delhi 110025, India   Email: eb.raman@ncl.res.in
,
Akash Mondal
a  Catalysis Division, Dr. Homi Bhabha Road, CSIR-National Chemical Laboratory (CSIR-NCL), Pune 411008, India
b  Academy of Scientific and Innovative Research (AcSIR), New Delhi 110025, India   Email: eb.raman@ncl.res.in
,
Ayesha Begum
a  Catalysis Division, Dr. Homi Bhabha Road, CSIR-National Chemical Laboratory (CSIR-NCL), Pune 411008, India
,
a  Catalysis Division, Dr. Homi Bhabha Road, CSIR-National Chemical Laboratory (CSIR-NCL), Pune 411008, India
b  Academy of Scientific and Innovative Research (AcSIR), New Delhi 110025, India   Email: eb.raman@ncl.res.in
› Author Affiliations
Further Information

Publication History

Received: 12 April 2017

Accepted after revision: 30 May 2017

Publication Date:
11 July 2017 (online)

Dedicated to Professor David Milstein on the occasion of his 70th birthday

Published as part of the Special Topic Cobalt in Organic Synthesis

Abstract

A facile cobalt-catalyzed N-alkylation of amines with alcohols using inexpensive, commercially available CoCl2·6H2O is reported. Employing this readily available cobalt catalyst, a variety of amines with wide functional group tolerance were selectively alkylated under benign conditions.

Supporting Information

 
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